TLR4 down-regulation identifies high risk HPV integration in head and neck squamous cell carcinomas

1Department of Clinical and Experimental Medicine, Section of Pathological Anatomy, University of Foggia, Foggia, Italy, 2Laboratory of Preclinical and Translational Research, IRCCS-CROB, Oncological Reference Centre of Basilicata, Rionero in Vulture (PZ), Italy, 3Section of Pathological Anatomy, Polytechnic University of Marche, Ancona, Italy, 4Section of Pathological Anatomy, National Cancer Institute IRCCS ‘G. Pascale’ Foundation, Napoli, Italy, 5Department of Laboratory and Services, Section of Histopathology, Research and Care Foundation ‘Giovanni Paolo II’, Catholic University of Sacred Heart (UCSC), Campobasso, Italy, 6Department of Surgical, Oncological and Stomatological Disciplines (Di.Chir.On.S.), University of Palermo, Via del Vespro 129, 90127 Palermo, Italy, 7Department of Sciences for the Promotion of the Maternal and Childhood Health “G. D’Alessandro”, Section of Anatomic Pathology, University of Palermo, A.O.U. Policlinico “P. Giaccone”, Palermo, Italy, 8Department of Neurosciences and Reproductive and Odontostomatological Sciences, University of Napoli ‘Federico II’, Napoli, Italy, 9Department of Advanced Biochemical Sciences, Section of Anatomic Pathology, University of Napoli Federico II, Via S Pansini 5, Napoli, Italy, 10Department of Experimental and Clinical Medicine, Dental Clinic, University of Foggia, Foggia, Italy, 11Section of Clinic Pathology, OO.RR., Foggia, Italy, 12Department of Head and Neck Surgery, Second University of Naples, Naples, Italy, 13Department Medical-Surgical Specialties, Section of Oral Medicine, Policlinico, University of Catania, Catania, Italy